CII.—Optically active dimethoxysuccinic acid and its derivatives

Effect of vanillin and its acid and alcohol derivatives on the diphenolase activity of mushroom tyrosinase

For the first time in the present study the effects of vanillin, vanillyl alcohol, vanillic acid, as well as the newly synthesized vanillin derivative, bis-vanillin, were investigated on the oxidation of dopamine hydrochloride by mushroom tyrosinase. Among them, vanillin and bis-vanillin act as activators, while vanillyl alcohol and vanillic acid exhibited inhibitory effects, the IC50 values be...

Effects of Lysergic Acid and Its Derivatives on Rhinencephalic Electrograms

Experiments on the Catabolism of Caproic Acid and Its Derivatives

The present paper contains the resuhs of experiments aiming at obtaining evidence of the modes of catabolism followed by normal fatty acids when undergoing so called p-oxidation in the animal body. Knoop’s theory of p-oxidation simply postulates the removal of successive pairs of carbon atoms without indicating the mechanism of the process. The common excretion of phydroxybutyric acid with acet...

Metabolic Therapy: Cardioprotective Effects of Orotic Acid and Its Derivatives

Metabolic therapy involves the administration of a substance normally found in the human body to enhance cellular reactions involved in the pathogenesis of disease. Myocardial ischaemia/reperfusion injury represents a leading cause of morbidity and mortality, also in cardiovascular disease. Therapeutic strategies aimed at limiting cardiomyocyte death during the postischaemic reperfusion and in ...

Cinnamic Acid and Its Derivatives Inhibit Fructose-Mediated Protein Glycation

Cinnamic acid and its derivatives have shown a variety of pharmacologic properties. However, little is known about the antiglycation properties of cinnamic acid and its derivatives. The present study sought to characterize the protein glycation inhibitory activity of cinnamic acid and its derivatives in a bovine serum albumin (BSA)/fructose system. The results demonstrated that cinnamic acid an...